Help Find a Cure for Breast Cancer

by Lynn Sage Breast Cancer Foundation
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Help Find a Cure for Breast Cancer
Help Find a Cure for Breast Cancer
Help Find a Cure for Breast Cancer
Help Find a Cure for Breast Cancer
Help Find a Cure for Breast Cancer
Help Find a Cure for Breast Cancer
Help Find a Cure for Breast Cancer

It is with great excitement that we announce our 3rd Lynn Sage Scholar, Dr Chonghui Cheng, MD, PhD. Dr. Cheng received her medical degree from Peking University, Beijing, China and her PhD in Biochemistry with Dr. Stewart Shuman at Sloan-Kettering Institute, New York. Dr. Cheng then moved to Boston and did her postdoctoral training with Noble Laureate Phillip Sharp at the Center for Cancer Research, MIT.  In August of 2007, Dr. Cheng joined the faculty at the Northwestern University of Hematology/Oncology as an Assistant Professor.

Research in Dr. Cheng's lab focuses on investigating the biological and components and pathways that control tumor metastasis and recurrence, which represent the two major obstacles in the successful treatment of cancer.

For carcinoma cells to break away from neighboring cells and invade to distal organs, they must lose cell-cell contact and become motile and invasive. These changes in cancer cell properties are governed by a process named epithelial-mesenchymal transition (EMT). Currently, the Cheng lab is investigating, at the molecular level, a critical role of several gene products in promoting EMT and breast cancer progression. They hope that their studies on dissecting the mechanisms of EMT and tumor progression may offer new strategies to predict disease prognosis and lead to identification of the therapeutic agents in inhibit EMT, thereby halting tumor progression.

Outside of work, Dr. Cheng enjoys cooking, sightseeing, and spending time with her family.

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With the passing of October and Breast Cancer Awareness month, we are wrapping up our third annual Chicago’s In Good Taste Campaign. While the total has not yet been tallied, we’re hoping to have doubled our results from last year’s $30,000.

This campaign united close to 150 local businesses, predominantly restaurants, during Breast Cancer Awareness Month. The ultimate goal for the participating restaurants, dining services, spas and other organizations was to raise money for breast cancer research. When guests dined at the participating establishments or utilize participating services, patrons had the opportunity to donate $1 or more to the Lynn Sage Foundation. All donations generated benefit the Lynn Sage Scholars Program at Northwestern University.

We’ve also been fortunate enough to be asked to be one of four beneficiaries for the LuxeHome Chill event which features 30 luxury LuxeHome boutiques hosting top Chicago-area chefs and superb wines from winemakers worldwide.

 “The Lynn Sage Foundation has given me the support to examine the role of obesity and obesity related genes in breast cancer.  This will help our breast cancer patients live longer and better lives.”

                -Virginia Kaklamani, MD, DSc, Assistant Professor, Division of Hematology/Oncology

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Our current Scholar, Dr. Virginia Kaklamani has been working to identifying patients at high risk for breast, ovarian and colon cancers based on their genetic background. Dr. Kaklamani has been looking at novel genes and individual risk based on changes in these genes and has been working on several genes and their relation to cancer risk, most notably TGF-beta and adiponectin. One change in TGF-beta has been shown to be associated with increased colon and breast cancer risk in individuals who carry it. Also adiponectin, which is also related to obesity and diabetes, has also been found to change breast and colon cancer risk. The result of this research will help identify correctly high risk patients and offer these individuals better preventative measures (such as oophorectomy) or better screening strategies such as colonoscopies, MRIs of breast and more frequent mammograms.

Dr Kaklamani is also working on identifying risk factors for weight gain in women who are newly diagnosed with breast cancer. It has been shown that women with breast cancer gain weight and this weight gain increases the chance of recurrence of their cancer. Dr Kaklamani has initiated a study to evaluate breast cancer related weight gain, looking at genes that may be responsible for the weight gain as well as treatment related effects.

“The Lynn Sage Foundation has given me the support to examine the role of obesity and obesity related genes in breast cancer. This will help our breast cancer patients live longer and better lives.” -Virginia Kaklamani, MD, DSc, Assistant Professor, Division of Hematology/Oncology

As October, quickly approaches, we’re gearing up for our third annual Chicago’s In Good Taste Campaign. This campaign unites local businesses, predominantly restaurants, during Breast Cancer Awareness Month. The ultimate goal for the participating restaurants, dining services, spas and other organizations is to raise money for breast cancer research. When guests dine at the participating establishments or utilize participating services, patrons have the option to donate $1 or more to the Lynn Sage Foundation on the receipt of their purchase. Table cards, check presenters and posters explaining Chicago’s In Good Taste are provided to all partners. All donations generated benefit the Lynn Sage Scholars Program at Northwestern University. Last year we has over 100 participating restaurants and raised over $30,000.

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There’s no better way to celebrate mom (or the other important women in your life) then with a card on Mother’s Day. This year, The Lynn Sage Foundation launched a new campaign around Mother’s Day to raise much needed funds for breast cancer research. For every $25 donation made between May 1 and Mother's Day, The Lynn Sage Foundation sent out an eCard that wished that special someone a Happy Mother's Day and let her know a donation had been made in her honor to find a cure for breast cancer.

With the generous backing of Mesirow Financial, who matched the first $15,000 donate, we were able to raise over $34,000 to support the Lynn Sage Scholar at the Northwestern Universities Robert H. Lurie Cancer Center.

Our current Scholar, Dr. Virginia Kaklamani has been working to identifying patients at high risk for breast, ovarian and colon cancers based on their genetic background. Dr. Kaklamani has been looking at novel genes and individual risk based on changes in these genes and has been working on several genes and their relation to cancer risk, most notably TGF-beta and adiponectin. One change in TGF-beta has been shown to be associated with increased colon and breast cancer risk in individuals who carry it. Also adiponectin, which is also related to obesity and diabetes, has also been found to change breast and colon cancer risk. The result of this research will help identify correctly high risk patients and offer these individuals better preventative measures (such as oophorectomy) or better screening strategies such as colonoscopies, MRIs of breast and more frequent mammograms.

Dr. Kaklamani is also working on identifying risk factors for weight gain in women who are newly diagnosed with breast cancer. It has been shown that women with breast cancer gain weight and this weight gain increases the chance of recurrence of their cancer. Dr Kaklamani has initiated a study to evaluate breast cancer related weight gain, looking at genes that may be responsible for the weight gain as well as treatment related effects.

“The Lynn Sage Foundation has given me the support to examine the role of obesity and obesity related genes in breast cancer. This will help our breast cancer patients live longer and better lives.” -Virginia Kaklamani, MD, DSc, Assistant Professor, Division of Hematology/Oncology

Links:

Share on Twitter Share on Facebook

With the funds recently raised, Dr. Virginia Kaklamani has been working to identifying patients at high risk for breast, ovarian and colon cancers based on their genetic background. Dr. Kaklamani has been looking at novel genes and individual risk based on changes in these genes and has been working on several genes and their relation to cancer risk, most notably TGF-beta and adiponectin. One change in TGF-beta has been shown to be associated with increased colon and breast cancer risk in individuals who carry it. Also adiponectin, which is also related to obesity and diabetes, has also been found to change breast and colon cancer risk. The result of this research will help identify correctly high risk patients and offer these individuals better preventative measures (such as oophorectomy) or better screening strategies such as colonoscopies, MRIs of breast and more frequent mammograms.

Dr. Kaklamani is also working on identifying risk factors for weight gain in women who are newly diagnosed with breast cancer. It has been shown that women with breast cancer gain weight and this weight gain increases the chance of recurrence of their cancer. Dr Kaklamani has initiated a study to evaluate breast cancer related weight gain, looking at genes that may be responsible for the weight gain as well as treatment related effects. “The Lynn Sage Foundation has given me the support to examine the role of obesity and obesity related genes in breast cancer. This will help our breast cancer patients live longer and better lives.” -Virginia Kaklamani, MD, DSc, Assistant Professor, Division of Hematology/Oncology

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Organization Information

Lynn Sage Breast Cancer Foundation

Location: Chicago, IL - USA
Website:
Facebook: Facebook Page
Twitter: @lynnsage
Project Leader:
Gret Luhrs
Chicago, IL United States
$112,303 raised of $1,000,000 goal
 
1,590 donations
$887,697 to go
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