By 2050 an estimated 10 million people will die each year from antibiotic-resistant infections -- almost 90% of those in the developing world. To address this, Phages for Global Health is teaching scientists in Africa how to develop cheap, naturally occurring antibiotic alternatives (phages) that are effective against antibiotic-resistant bacteria. Phages have been used successfully against problem bacteria for >100 years in certain regions, but they have not yet been applied in Africa.
The global antibiotic resistance crisis disproportionately impacts developing countries such as those in Africa. Resistance has already developed in bacteria that cause pneumonia and diarrhea, the 2 leading causes of death in children under age 5. With few other treatment options available, researchers at numerous institutions in East and West Africa aspire to develop phages as antibiotic alternatives -- as is being done elsewhere globally -- but they do not yet have the expertise to do so.
Phages can be very beneficial in the developing world, since they can kill antibiotic-resistant bacteria, are easy to obtain from contaminated environments, inexpensive to manufacture, and safe. During 2018 we will run 2 separate two-week, hands-on laboratory training workshops -- 1 each in East and West Africa -- during which we will train a total of 50 African scientists how to isolate and characterize phages locally. These will expand the upon our successful pilot workshop held in 2017.
Phage products can be used to kill antibiotic-resistant bacteria in food, water, livestock and people, potentially saving thousands of lives -- if not millions. By giving African scientists the key skills, we will empower them to make antibacterial products that are both technically effective and socially accepted in their own countries. We will also continue to build a network of scientists in Africa and abroad who can collaborate and provide support for ongoing phage product development.
This project has provided additional documentation in a PDF file (projdoc.pdf).
National Veterinary Research Institute (partner)
Pwani University (partner)
Makerere University (partner)
University of The Gambia (partner)