Help Find a Cure for Breast Cancer

by Lynn Sage Breast Cancer Foundation
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Help Find a Cure for Breast Cancer
Help Find a Cure for Breast Cancer
Help Find a Cure for Breast Cancer
Help Find a Cure for Breast Cancer
Help Find a Cure for Breast Cancer
Help Find a Cure for Breast Cancer
Help Find a Cure for Breast Cancer
Dr. Horiuchi in Lab
Dr. Horiuchi in Lab

“We could not be more grateful for the support that The Lynn Sage Foundation has provided to us over the past two years,” comments prior Lynn Sage Scholar Dr. Horiuchi. 

His Lynn Sage Scholar award period concluded at the end of June 2019.  The theory he pursued, that the S100 family of calcium-binding proteins correlated with poor outcomes in Triple Negative Breast Cancer (TNBC) patients, was initially considered ambitious.  It could not have been considered for funding by federal sources at the time of his initial award.  Dr. Horiuchi knew his project would be highly challenging, but it was also unique and had potential for strong impact. 

“We firmly believe that nothing that could become impactful would come easily in biomedical research,” states Dr. Horiuchi.

Two years later, his team’s research has preliminarily validated the relationship of these proteins in the proliferation of TNBC tumors.  This research, while still growing, has gained the support of a nationally recognized immuno-oncology scientist.  Dr. Horiuchi’s team now has a track record to pursue publication and federal funding.  Most importantly, they will continue this line of investigation to establish the S100 proteins as novel immuno-oncology targets in TNBC. 

Throughout his investigations, Dr. Horiuchi remains rooted in his ultimate goal, to reduce the mortality rate for TNBC patients.  The Lynn Sage Foundation is similarly dedicated to funding innovative breast cancer research.  And, like Dr. Horiuchi, we could not be more grateful for support of our cause.  Investing in young doctors with novel theories is not without risk, but we believe we won’t end breast cancer without supporting ambitious minds. 

Thank you for contributing to the Lynn Sage Scholars Program and bold ideas in the fight against breast cancer!

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Lab Presentation Dr. Horiuchi
Lab Presentation Dr. Horiuchi

During October, many of our thoughts center on friends and family that have faced, or are fighting, breast cancer.   According to the National Cancer Institute, breast cancer is the most common and second most deadly cancer for women in the US.  Unfortunately, this awful disease brings fear to far too many women and men. 

 

The Lynn Sage Foundation believes research is key to improving the lives of those diagnosed with breast cancer.  However, it is very difficult for bright, young doctors to receive initial funding for their innovative ideas.  Our approach is simple.  The Lynn Sage Scholars program focuses on seeding early career researchers in the field of breast cancer.  These awards provide both time and funds to test novel theories, such as targeting a new molecular family for personalized medicine.  Our ultimate goal is to be the catalyst to better prevention and treatment of breast cancer for everyone. 

 

Medical research can be a lengthy process. Therefore, our immediate measure of success is the ability of each Scholar to leverage this investment into more significant governmental grants.   On average to date, one dollar invested by the Lynn Sage Scholars program results in an additional four dollars from nationally recognized institutions, such as the National Institutes of Health.  This impact will only continue to grow as the family of Lynn Sage Scholars pursue their investigations. 

 

Leverage your contribution, while helping set curious minds on the path to breakthrough.  Please consider honoring a loved one with a donation to the Lynn Sage Foundation and pioneering breast cancer research. 

Lab Presentation Dr. Horiuchi
Lab Presentation Dr. Horiuchi

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Danielle on her wedding
Danielle on her wedding

Danielle was a young newlywed anxiously awaiting her honeymoon when her gynecologist felt a lump. Her mother had often had benign lumps. With no family history of breast cancer, she decided to wait until life calmed down to get it checked. Instead, she focused on their trip of a lifetime to Thailand.

On the day they returned from their honeymoon, her husband, Joshua, discovered a concerning lump, which was determined to be testicular cancer. Unfortunately, his tumor had advanced to his lymph vessels and required chemotherapy. Because of Joshua’s diagnosis and urging, Danielle revisited her own lump. She was diagnosed with stage one breast cancer.

Danielle feels fortunate her cancer was detected early. Her treatment plan was a double mastectomy followed by Tamoxifen, a drug used to treat certain breast cancers. Both were challenging, but ultimately positive. Strangely, the most trying complication was due to being diagnosed at such a young age.

“Both my husband and I getting diagnosed before we had kids added another element to our process. We had to freeze our sperm and eggs in the event we wouldn’t be able to conceive naturally after treatments. Emotions were already running high. Then having your husband give you shots of hormones for two weeks after his chemotherapy treatments was very difficult. It was not what we envisioned our first few months of marriage would be like, but it was important that we didn’t lose out on the opportunity to have our own children.”

Finding Perspective Through a Difficult Diagnosis

One cancer diagnosis is overwhelming, let alone two consecutively. Danielle encourages anyone facing breast cancer to take it one step at a time and allow yourself to feel all the emotions. It was after recovering from surgery that she developed a love of running. Exercise supported her physical recovery, but it also helped her process the various emotions.

Today, Danielle and Joshua are healthy and cancer-free! She is training to compete in the Bank of America Chicago Marathon this October with Team Lynn Sage and focusing on the positives gained from this unfortunate diagnosis.

“It made me realize how lucky I am to have such wonderful family and friends. Without their love and support, I would have struggled much more emotionally during diagnosis and treatment.”

“Having cancer also helped me recognize that you never know what turns life has in store. We all need to live our life to the fullest. I don’t sweat the small stuff like I did before being diagnosed. The little things, like missing my train or my dog having an accident in the house, are just insignificant. I know how much worse it could be.”

 The Power of Research

It was during medical leave that Danielle was introduced to The Lynn Sage Foundation. A friend from work invited her to attend Summer Toast. She knew she was benefiting from the progress of research and was excited to get involved once she was fully recovered.

“Unfortunately, breast cancer will likely touch someone you love at some point. The more you learn about the disease, the more you’ll be able to help. By supporting research with your time, energy and resources, you make a difference in the lives of those diagnosed. Or even better, prevent a diagnosis!”

Your support of the Lynn Sage Scholars helps improve the lives of all those diagnosed with breast cancer, no matter their age, race or gender.  Thank you!

Danielle & Josh
Danielle & Josh
Danielle race day
Danielle race day

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Summer Toast
Summer Toast

Summer is the perfect time to connect with family and friends in support of causes near to you.  The Lynn Sage Foundation is has crafted some wonderful opportunities to welcome summer and support innovative breast cancer research!  We hope to see you soon!

The Associate Board hosts our annual festive happy hour, Summer Toast, at Joy District on June 26th.  This fun night includes a beautiful crowd of over 200 young professionals toasting, noshing and mingling after work.  Most importantly, it provides a wonderful opportunity to meet current Lynn Sage Scholar, Dr. Ji, and learn more about his pioneering genomic sequencing research.  Tickets and raffle sales benefit the Lynn Sage Scholars program.

Training kicks off for the Chicago Marathon in the next few weeks.  Team Lynn Sage has an outstanding group of athletes running and fundraising on behalf of the Lynn Sage Scholars program and breast cancer research.  We’re incredibly grateful and excited to support this crew as they prepare for October 13th race day.  If you see Team Lynn Sage shirts when you’re out on the running path, give them a high five!

If golf is your preferred summertime activity, come out to support The Lynn Sage Foundation at Foursomes 4 Philanthropy on September 22nd.  This Sunday Funday outing includes a four-person scramble at White Deer Run Golf Course, dinner, and a meaningful donation to two great causes. 

Join us at one of these fun events or contact us any time.  We’d love to hear from you and share more about The Lynn Sage Foundation!

TLS
TLS
Summer
Summer

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Dr. Ji
Dr. Ji

The Lynn Sage Foundation is proud to announce the ninth Lynn Sage Scholar, Zhe Ji, Ph.D.

Dr. Ji is an Assistant Professor of Pharmacology and Biomedical Engineering at Northwestern University Feinberg School of Medicine.  He joins a prestigious group of current and former Lynn Sage Scholars diligently investigating new approaches to the detection and treatment of breast cancer.

“I am really excited to be selected as a Lynn Sage Scholar. I am deeply grateful for the generous funding of the genomics research in my lab as we tackle breast cancer, " commented Dr. Ji on receiving the Lynn Sage Scholar award.  

"My lab carries out data-driven research, performs cutting-edge genomic sequencing experiments, and develops novel computational tools for integrative data analyses using machine learning and deep learning. The Lynn Sage Foundation provides us with an invaluable resource to pursue a brave idea for the cancer research in my lab.” 

Dr. Ji’s group is studying the steps of breast cancer progression by dissecting the gene regulatory network and RNA translation.  As a Lynn Sage Scholar, Dr. Ji and his team will use unbiased, high-throughput genomic sequencing technologies and computational modeling in their project, “Characterizing the Gene Regulatory Landscape Mediating Breast Cancer Metastasis”.  His group’s ultimate goal is to reveal novel therapeutic strategies for personalized cancer treatment.  

Dr. Ji joined Northwestern University in 2018 and is a member of the Robert H. Lurie Comprehensive Cancer Center.  He received his Ph.D. in computational genomics from Rutgers University in 2012 and completed his postdoctoral training in cancer systems biology and computational biology at Harvard Medical School and the Broad Institute of MIT and Harvard in 2017.  Dr. Ji has received the NIH Pathway to Independence Award (K99/R00), the Searle Leadership Fund in the Life Sciences from Northwestern University, and the Dean Morris Schaffer Endowed Scholarship from Rutgers University. 

We look forward to personally introducing Dr. Ji to The Lynn Sage Foundation community at Summer Toast later this year. 

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Organization Information

Lynn Sage Breast Cancer Foundation

Location: Chicago, IL - USA
Website:
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Twitter: @lynnsage
Project Leader:
Gret Luhrs
Chicago, IL United States
$112,303 raised of $1,000,000 goal
 
1,590 donations
$887,697 to go
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