Help find a cure for HIV/AIDS

by AIDS Research Alliance

Summary

AIDS Research Alliance has helped develop half of the drugs approved for treatment of HIV/AIDS (HAART). Now we're working on a cure strategy. Our lead candidate - prostratin - was a drug first identified at NCI (NIH). In an infected person, HIV hides in "reservoirs" within blood cells, increasing the challenge of eradicating the virus. Our scientists need access to an important technology, "leukapheresis," to gauge how efficiently prostratin activates the hidden virus in an infected person.
$50,000
total goal
$39,299
remaining
113
donors
0
monthly donors
3
years active

Challenge

In an HIV-positive person, even if under treatment, HIV hides in "reservoirs" within blood cells, making it invisible to current treatment therapies. This latent virus is the single most persistent obstacle to finding a cure for HIV/AIDS.

Solution

Prostratin, first identified at the National Cancer Institute as being effective against HIV, forces this latent virus to reveal itself. This allows current treatments to eradicate HIV from the person's body. It will be valuable to our scientists to gauge how efficiently prostratin activates the hidden virus from actual infected patients. This technology, "leukapheresis," will facilitate the next step in our search for a cure.

Long-Term Impact

This technology will facilitate the extraction of a patient's reservoir cells needed to conduct our studies. Our ability to access this technology will play a critical role in our progress towards Phase I in the FDA approval process for prostratin, and ultimately, our search for a cure for HIV/AIDS.

Resources

http:/​/​www.aidsresearch.org/​
Background on HIV/​AIDS cure research
Eradicating HIV reservoirs
About Prostratin
Our Progress in finding a cure

Organization Information

AIDS Research Alliance

Location: Los Angeles, CA - USA
Project Leader:
Emma Brownell
Los Angeles, CA United States

Funded Project!

Combined with other sources of funding, this project raised enough money to fund the outlined activities and is no longer accepting donations.

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