By Amanda Freeman, Ph.D. | The mechanism underlying GABA and hypersomnia
Dr. Freeman earned her PhD in Neuroscience at Emory University for research identifying a novel neuroanatomical pathway that linked dopamine to sleep regulatory circuits and has remained at Emory since that time. Her current research to explore the genetic basis of Restless Legs Syndrome led to the first model of a human sleep disorder in Drosophila. She has been able to collaborate with a team of clinicians and basic researchers to discern the mechanism underlying GABA-related primary hypersomnia. The recent identification that hypersomnia may be caused in many cases by an endogenous peptide that accumulates in the brain and mimics the actions of sedatives and anesthetics, has attracted considerable attention since its discovery in 2012.
The Hypersomnia Foundation, in partnership with Dr. Freeman, created a video that explains the mechanisims of GABA in part 1 of a 2 part series. These videos are being produced as part of the Hypersomnia Foundation's programs to increase awareness and education of research in primary hypersomnia and will be placed on its website for all interested viewers.
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