St. Jude Children's Research Hospital

Fundraisers at Work Help St. Jude Save Lives
Fundraisers at Work Help St. Jude Save Lives

Survival rates for childhood cancer of 80 percent are great, but with support from you and others like you, we’re working to drive it to 90% by 2020.

How do your donations help?

  • Thanks to donors, no family ever pays St. Jude for anything. Care, housing, transportation, meals—the list of services we provide to our families is unequalled. But it is for one purpose: To ensure the very best outcome possible for every child.
  • At St. Jude, donor dollars help fuel the groundbreaking research that leads to pioneering care and treatments for childhood cancer and other deadly diseases.

How is St. Jude making a difference for sick children?

  • Every child saved at St. Jude means children saved around the world—a direct result of cutting-edge research and treatment that set the standard in treating childhood cancers. And our discoveries are shared freely with doctors and scientists all over the world.
  • St. Jude developed protocols that have helped push overall survival rates for childhood cancers from less than 20 percent, when the hospital opened in 1962, to 80 percent today.
  • St. Jude is the first and only pediatric cancer center to be designated as a Comprehensive Cancer Center by the National Cancer Institute.
  • St. Jude has embarked on an unprecedented effort to sequence the pediatric cancer genome and to identify the genetic changes that give rise to some of the world's deadliest childhood cancers. Read more.

How are donations used?

  • During the past five years, 81 cents of every dollar received has supported the research and treatment at St. Jude Children's Research Hospital.
  • It costs $1.9 million a day to operate St. Jude, and public donations provide more than 75 percent of our funding.

To fundraise at your work, you may visit



5 years old



Ethan was found to suffer from pineoblastoma in June 2012.



These days, when Ethan’s mom cues up her Zumba workout in the living room, she soon fi nds that she’s not dancing alone.  Ethan, her 5-year-old son, has appeared right next to her in front of the TV screen. He loves learning and repeating the dance steps, he loves the music and he loves his mom.  As his mom looks down at Ethan happily stamping and sliding his little feet, she is grateful for many things. But her heart swells with gratitude for two blessings in particular: St. Jude Children’s Research Hospital and mother’s intuition.

When Ethan was 3 years old, he began vomiting, became lethargic and lost interest in food and play. Doctors chalked it up to allergies or possibly a virus. But when his symptoms failed to subside, his mother, a nurse, took him to the emergency room. There, doctors theorized that Ethan was having migraines.

“When we left the ER, I was in tears,” Ethan’s mom remembers.  “I knew in my heart that something wasn’t right. I knew it was something else, that it was serious.”

At her insistence, Ethan’s pediatrician sent him to the local children’s hospital. That’s where a CT scan revealed that Ethan suffered from a rare and dangerous brain tumor known as pineoblastoma.

Ethan was slated for brain surgery. But prior to that date, “people just kept telling us about St. Jude, and St. Jude kept coming up,” recalls his mom.

She didn’t yet know that St. Jude has the largest pediatric brain tumor research program in the country and the world’s best survival rates. She just knew St. Jude was where Ethan needed to be.

At St. Jude, Ethan first underwent chemotherapy to shrink the cancerous tumor in his brain, then surgery to remove the tumor, followed by radiation therapy and more chemotherapy.

Ethan is now cancer-free and returns to St. Jude every three months for checkups.

The lifesaving interventions were hard on Ethan’s body. He was often fatigued and didn’t want to eat.  Receiving physical, speech, and occupational therapies at St. Jude helped Ethan recover.

Now, Ethan shows off his line-dancing moves at every opportunity. He also loves to play his toy instruments and practice writing his ABCs, and he is excited about pre-kindergarten this year. And his mom loves it when he joins in on her Zumba routine, when she can bask in just how far he’s come.

Mae, 6 years old

Diagnosis: Mae was found to suffer from Wilms tumor in October 2010.

Mae’s story: Mae is a girly girl. She loves dolls, the color pink and glitter – lots and lots of glitter. On this particular day, Mae goes through a large box full of dress up clothes. There are princess dresses, fairy wings and dance costumes to sort through. Mae finds what she’s looking for, a frilly pink dress full of sparkles. She puts on the dress and a bejeweled tiara, then poses in front of the mirror, a princess ready for the ball.

In 2010, Mae’s family was devastated to learn that she suffered from Wilms tumor, a solid tumor of the kidney. She received treatment at a local hospital, which included surgery to remove the tumor and her left kidney, chemotherapy and radiation therapy.

But in March 2012, Mae’s cancer returned. This time, her family turned to St. Jude Children’s Research Hospital for her continuing treatment. Mae’s mother grew up in Memphis and knew about the hospital.

“St. Jude has a wealth of knowledge about this type of cancer,” said Mae’s mother. “That’s where we wanted to be.”

At St. Jude, Mae’s treatment included chemotherapy and radiation therapy. “The care at St. Jude is so comprehensive,” said her mother. “It’s so team-oriented.”

While undergoing treatment at St. Jude, Mae became friends with other patients undergoing treatment for Wilms tumor. “We didn’t have this community the first time around,” her mom said. “Mae’s St. Jude friends can be there for her in a way I can’t.”

Mae is done with treatment and now visits St. Jude for regular checkups. She looks forward to coming back to the hospital so she can see her friends and her doctors and nurses. Mae, who has two sisters, loves paper dolls, making beaded jewelry and playing with Barbies.

Recently, Mae participated in the kindergarten graduation at St. Jude. She donned a cap and gown and beamed brightly when she received her diploma. She’s looking forward to starting first grade this fall.


Pain management for 5-year-old Bo is child
Pain management for 5-year-old Bo is child's play

Scientists are mining the genetic code to better match patients and medications now and in the future.

His broad smile signals that 5-year-old Joshua “Bo” Carter is having a good day. Before beginning the family’s weekly trip to St. Jude Children’s Research Hospital where he undergoes treatment for acute lymphoblastic leukemia (ALL), Bo’s mother packed his favorite superhero action figures and a selection of small race cars. Now Bo makes the toys zoom through a hospital play area as he waits to start treatment. During the two-hour intravenous immune-system boost, Bo will pass the time by watching Tom & Jerry cartoons.

This week has been easy for Bo, who is more than halfway through an expected two-and-a-half years of cancer treatment. It has offered a break from chemotherapy that consists of vincristine and other drugs. Vincristine is part of the chemotherapy cocktail that helped St. Jude push its long-term ALL survival rates to 94 percent. The drug works by preventing or slowing the growth of cancer cells, but it can also cause severe pain.

Thanks to a multidisciplinary St. Jude research team, Bo’s doctors have new tools to help them select the best medication to manage his pain. Those tools include an automatic computer warning that appears on screen if a health care provider attempts to prescribe the drug codeine. A genetic test done shortly after Bo began cancer treatment showed that codeine would not ease his pain. The test revealed that Bo belongs to the estimated 10 percent of the population who lack the gene that makes the enzyme needed to activate codeine into the pain-reliever morphine.

Now when he receives vincristine, Bo goes home with alternate pain relievers.

“I had no clue that genes could affect whether or not a drug like codeine gave you any relief,” says Michelle, his mom. “I just know that life gets back to normal when he is feeling better, and he’s up playing and running around.”

Understanding differences in drug response

Prescription bottle

What is pharmacogenetics?

Pharmacogenetics unites the fields of genetics and pharmacology to better understand how small differences in genes affect a person’s response to drugs. The St. Jude PG4KDS project uses pharmacogenetics as a tool to help improve medication safety and effectiveness.

The science of pharmacogenetics has made personalized medicine possible for patients like Bo. Pharmacogenetics got its start in the 1950s when investigators realized certain medicines were more likely to trigger side effects in specific ethnic groups. Scientists also showed that the side effects tended to be inherited. Pharmacogenetics shows how countless small differences in genes affect each person’s response to drugs—good, bad or indifferent.

In the 1990s, St. Jude researchers offered an important early example of pharmacogenetics’ power to improve patient care. A team led byWilliam E. Evans, PharmD, now St. Jude director and chief executive officer, linked life-threatening complications associated with an important family of cancer drugs to variations in a single gene. The gene was TPMT. It carries instructions for making an enzyme of the same name that metabolizes medicines known as thiopurines. The variations mean that as many as one in 10 patients may need a lower dose of the drugs; one in every 400 individuals needs a substantially smaller amount to avoid potentially deadly side effects.

Today, work continues to identify which of the estimated 18 million gene variations in the human population plays an important role in drug response. So far, investigators have tied differences in hundreds of genes to differences in the activity of particular drugs, including how they are metabolized and transported. St. Jude researchers are at the forefront of a national effort to develop ways to translate the research into clinical tools.

Mary Relling, PharmD, and James Hoffman, PharmD

Pharmaceutical Sciences Chair Mary Relling, PharmD, discusses expansion of the PG4KDS study with James Hoffman, PharmD, the hospital’s medication outcomes and safety officer.

“There are now several medications that are so strongly affected by genetic variation; if we can test patients before they are treated with those medications, we have an opportunity to choose a better drug or a better dose of the drug right from the start. For these medicines, using genetics to inform prescribing means that therapy is safer and more effective,” says Mary Relling, PharmD, St. Jude Pharmaceutical Sciences chair. “Because these medications are used for a number of different diseases, pharmacogenetics is not just important for children with cancer.”

Advances in gene tests mean that for a few hundred dollars it is now possible to screen 225 genes for about 1,900 differences implicated in drug metabolism. The technology meets the high standards for use in the clinic, not just in the research laboratory. One gene can impact the workings of as many as 30 or 40 different drugs. The lower cost now makes it possible to test such genes early in treatment so results are available before prescribing medications. Because genetic test results are lifelong, a single test can offer prescription guidance throughout a patient’s life.

From research findings to clinical applications

The challenge is developing a system to integrate the information into clinical care. Busy doctors need a way to use complex genetic test results for prescription decisions and to keep up with new findings.

St. Jude launched the ongoing PG4KDS study to develop solutions. Relling is the principal investigator of the study, which has enrolled more than 500 patients, including Bo, since opening in 2011. Ultimately all St. Jude patients will have a chance to join.

PG4KDS uses a blood sample to check for variations in 225 genes. Currently, results for two genes are added to a patient’s medical record. For now the remaining pharmacogenetic results are stored in a research database. Relling and her colleagues say additional genes, with rules linked to the drugs they affect, will be added to patient medical records when evidence is strong enough. Tools must also be available to help medical providers use the results to make prescribing decisions now and for years to come. Relling leads an international group, the Clinical Pharmacogenetics Implementation Consortium, which is writing rules to help expand use of pharmacogenetic testing as a tool to improve patient care.

“We want to be the bridge between research and clinical care,” explains Kristine Crews, PharmD, of Pharmaceutical Sciences.

PG4KDS is having an impact. Tools developed for the study and the hospital’s switch to electronic medical records are helping translate the genetic test results into patient care decisions. The changes include automatic computer alerts that signal a clinician to change a medication dose or pick a different drug.

“Pharmacogenetics helps us act earlier to avoid complications and, in the case of patients like Bo, ease symptoms,” says Hiroto Inaba, MD, PhD, Oncology. For Bo and his family, pharmacogenetics has not only made cancer a little easier to endure but has also raised questions about whether the same variations might influence other family members’ responses to medication.

St. Jude parents played an important role in designing PG4KDS. Because patients and parents want to understand how tests might impact their care now and in the future, they can receive test results directly as they are added to the medical record.

Parents of St. Jude patients also helped create an educational video about PG4KDS. to watch the video.


Aidan - 4 years old
Aidan - 4 years old

4 years old

The default player for embedding or displaying video on 


Aidan was found to suffer from pilocytic astrocytoma in December 2010.

Aidan's story:

Aidan is a blur of motion. One moment he’s standing at the giant chalkboard in his playroom, drawing circles and squares with chalk.

The next minute he’s crouched down in front of his train table, lining up train cars. And then he’s out the backdoor with his older brother, racing toward the swing set.

Aidan’s parents delight in their youngest son’s zest for life. For a while, they worried about what his future might hold.

In early 2010, Aidan seemed to stop developing as quickly as his siblings. His parents had difficulty understanding him and his balance was off. That June, Aidan was found to suffer from neurofibromatosis, a disorder that causes tumors to grow on the nerves.

Aidan’s parents barely had time to process that news when, six months later, scans revealed a tumor growing in Aidan’s right optic nerve. He was immediately sent to St. Jude Children’s Research Hospital, where further tests revealed a second tumor in Aidan’s left optic nerve. The tumors were identified as pilocytic astrocytomas.

At St. Jude, Aidan underwent chemotherapy for 18 months. Because of the location of the tumors, they are inoperable. Doctors know they will begin to grow eventually, and when they do, Aidan will again undergo chemotherapy. “His cancer will never go into remission,” said Aidan’s mother. “He’ll have chemotherapy on and off for the rest of his life.”

Despite this daunting outlook, Aidan’s family has bright hopes for his future. “He’s a happy child, he’s in school and doing well,” said Aidan’s mom. “With everything he’s been through, he’s taught us to just be happy every day.”

Aidan’s parents are grateful for the people who help support St. Jude. “We never have to worry about a bill. When you have a child who is going to have a lifetime of treatment, this means so much,” Aidan’s mom said.

Aidan returns to St. Jude for regular checkups. He loves to see his doctors and nurses, and he especially loves playing with the trains in the playrooms.


January 2013

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Project Leader

Elizabeth Ashford

Memphis, TN United States

Where is this project located?

Map of St. Jude Children's Research Hospital