GRAACC is one of the few hospitals in Brazil that performs the haploidentical transplantation, bone marrow transplantation - donor BMT with just 50% compatibility, which is possible only when the donor is the father, mother or child. Normally, there are three options for bone marrow transplantation: one with family donor, completely identical in general; another with a non-related donor, preferably 100% identical; and another with umbilical cord blood, which may be wholly or partially identical. The search for a donor, however, may take several months and, in some cases, cancer patients who need to do this type of transplant are in line at the bone marrow bank for long. This is because the Brazilian population there is a huge mixture of races and the greater genetic diversity, the less chance of getting a compatible donor. "Although Brazil has the third largest bank in the world, a chance to find a compatible unrelated donor is around 1 to 1 million. The Japanese and German banks, for example, smaller than ours, are suitable donors more easily due to poor mixing, "said Dr. Victor Zecchin, medical oncologist and specialist in pediatric BMT GRAACC. Alternatively, some years large global transplant centers has been proposing the realization of haploidentical transplants, and one of them is GRAACC. According Zecchin, in these cases we use a donor with half of compatibility, preferably the mother rather than the father, because during pregnancy there is passage of fetal cells to the mother's circulation. Thus, the mother develops greater tolerance to minimize the risk of serious complications after transplantation. This option is according to position and time of each patient. The process, which has been widely discussed internationally and with promising results, in Brazil is on a national scale development phase. There is still the fear of generating serious infectious complications, the risk of rejection and increased risk of the disease returning. "But even with this probability, this risk is worth it because it is better than the patient to spend months waiting for the donor and risk losing the most appropriate time to undergo transplantation. And of course, there is a case that should be analyzed, "said Zecchin.
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