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Identify/understand all Alzheimer's-related genes



Cure Alzheimer's Fund is focused on funding research with the highest probability of slowing, stopping or reversing Alzheimer's Disease.

What is the issue, problem, or challenge?

The Alzheimer's Genome Project, funded by Cure Alzheimer's Fund, has identified more than 100 candidate genes thought to contribute to or guard against Alzheimer's pathology. Our immediate focus will now be to confirm and prioritize those genes to yield approximately the top two dozen genes that both a) have a high genetic impact (are both prevalent in the general population and play a significant role in AD); and b) influence biological pathways that are most susceptible to drug treatment.

How will this project solve this problem?

We will fund research focused on the highest-priority 'hits' as defined by genetic ranking to see what those genes actually do and whether the biological processes in which they are involved might be amenable to modification by drugs.

Potential Long Term Impact

An estimated 35 million people worldwide have Alzheimer’s, expected to skyrocket to 115 million by 2050. AD is the 6th leading cause of death and is the only one of the major diseases to be increasing in mortality. Research is the key to progress.

Funding Information

Total Funding Received to Date: $16,623
Remaining Goal to be Funded: $83,377
Total Funding Goal: $100,000

Additional Documentation

This project has provided additional documentation in a Microsoft Word file (projdoc.doc).


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Cure Alzheimer's Fund

Wellesley Hills, Ma, United States

Project Leader

Laurel Lyle

Wellesley Hills, MA United States

Where is this project located?

Map of Identify/understand all Alzheimer's-related genes
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